Free Essays on Muslims

â€Å"Muslim society had a sophistication matched at that time only by the Tang Empire of China.† (Mcdougal Littell, 242) The Muslim society was very advanced in many ways compared to the societies of other major civilizations. They made great advancements in the blending of cultures, math and science, and arts and literature. All this made possible the a semblance of the House of Wisdom, a combination library academy, and translation center. Muslim culture was centered around its four social classes. It included the born Muslims at the top. Converts were in the next class and had to pay higher taxes than the born Muslims. Next came the non-Muslim people who paid the most taxes of them all. The lowest class were the slaves, all of whom were non-Muslim. Muslims believed that math was the basis of all knowledge. A Muslim first described â€Å"al-jabr†, which we still use today as Algebra. Many of the Muslim’s researched of math lead to scientific discoveries. Astronomy and Optics were two fields in which the Muslims greatly excelled in. Ibn Haytham was the person to discover that rays pass from object to eyes. Literature was a strong tradition to the culture All literature stemmed from things such as bravery, love, generosity, and hospitality. All the culture’s literature was based on the sacred Qur’an. Muslims also had a deep interest in art, though they had to come up with inter esting ways to do it. Islam forbid the painting of humans. So artist came up with creative ways to do it, for example using calligraphy. But the most beautiful thing from their culture was the architecture. Though Muslims are now regarded as back-wards in their ways of women. In this particular time period Muslim women had more rights than most women. Poor women could work along side their husbands and the rich ones overlooked servants and could even get an education.... Free Essays on Muslims Free Essays on Muslims â€Å"Muslim society had a sophistication matched at that time only by the Tang Empire of China.† (Mcdougal Littell, 242) The Muslim society was very advanced in many ways compared to the societies of other major civilizations. They made great advancements in the blending of cultures, math and science, and arts and literature. All this made possible the a semblance of the House of Wisdom, a combination library academy, and translation center. Muslim culture was centered around its four social classes. It included the born Muslims at the top. Converts were in the next class and had to pay higher taxes than the born Muslims. Next came the non-Muslim people who paid the most taxes of them all. The lowest class were the slaves, all of whom were non-Muslim. Muslims believed that math was the basis of all knowledge. A Muslim first described â€Å"al-jabr†, which we still use today as Algebra. Many of the Muslim’s researched of math lead to scientific discoveries. Astronomy and Optics were two fields in which the Muslims greatly excelled in. Ibn Haytham was the person to discover that rays pass from object to eyes. Literature was a strong tradition to the culture All literature stemmed from things such as bravery, love, generosity, and hospitality. All the culture’s literature was based on the sacred Qur’an. Muslims also had a deep interest in art, though they had to come up with inter esting ways to do it. Islam forbid the painting of humans. So artist came up with creative ways to do it, for example using calligraphy. But the most beautiful thing from their culture was the architecture. Though Muslims are now regarded as back-wards in their ways of women. In this particular time period Muslim women had more rights than most women. Poor women could work along side their husbands and the rich ones overlooked servants and could even get an education....

Documentos para green card por matrimonio con ciudadano

Documentos para green card por matrimonio con ciudadano La documentacià ³n para sacar la tarjeta de residencia por matrimonio con un ciudadano es numerosa y conviene tenerla en mano o al menos solicitada antes de empezar la tramitacià ³n. En este artà ­culo se distingue, para hacerlo ms claro, entre los trmites que se realizan cuando el cà ³nyuge extranjero est ya en los Estados Unidos y se sigue lo que se conoce como un ajuste de estatus. Y tambià ©n cuando se da la circunstancia de que est en otro paà ­s y se sigue lo que se llama procedimiento consular. Recordar, antes de empezar, que en los Estados Unidos producen los efectos migratorios los matrimonios entre una mujer y un varà ³n que los de personas del mismo sexo. Lo à ºnico que se pide en este à ºltimo caso, es que la boda se celebre en un lugar cuyas leyes permiten el matrimonio gay. Documentos para la tarjeta de residencia por matrimonio con ciudadano por ajuste de estatus Las personas extranjeras presentes en Estados Unidos pueden obtener la residencia, tambià ©n conocida como green card, por matrimonio con un ciudadano mediante un ajuste de estatus siempre y cuando hubieran ingresado al paà ­s de forma legal, con una visa o mediante el Programa de Exencià ³n de Visas. Es decir, no pueden hacerlo aquellas personas que ingresaron ilegalmente a los Estados Unidos. Los migrantes que se encuentren en esta situacià ³n deben asesorarse con un abogado de confianza antes de iniciar los trmites. Ello es porque a mitad de los mismos tendrn que salir del paà ­s y, en la mayorà ­a de los casos, tendrn una prohibicià ³n para regresar por 3 o 10 aà ±os. Es necesario informarse para estudiar honestamente si existe alguna posibilidad de regularizar la situacià ³n sin necesidad de salir del paà ­s. Para los que pueden ajustar su estatus, pueden realizar en un solo paquete dos tramitaciones distintas: la peticià ³n de esposo y el ajuste de estatus. Los documentos son los siguientes: - Formulario I-130, peticià ³n de familiar - Copia certificada del acta de matrimonio. Si el casamiento se celebrà ³ en otro paà ­s, asegurarse de que cumple con todos los requisitos para ser considerado vlido en Estados Unidos. En este caso, si el documento o cualquier otro no est en inglà ©s, deber traducirse. Este es  un modelo de carta para hacer una traduccià ³n certificada  para Inmigracià ³n. - Prueba de la nacionalidad estadounidense: pasaporte americano, acta o certificado de nacimiento en Estados Unidos, certificado de naturalizacià ³n, acta de nacionalidad por ser hijo o hija de americano a pesar de haber nacido en el extranjero o cualquier otro documento que pueda ser admitido para probar la nacionalidad. - Del cà ³nyuge extranjero es necesario presentar copia certificada del acta o partida de nacimiento. Si no estuviera en inglà ©s, deber traducirse y certificarse dicha traduccià ³n. No es necesario obtener la apostilla de la Haya. - 6 fotografà ­as tipo pasaporte de cada uno de los cà ³nyuges (cada uno, la suya). - Formulario I-485 para ajuste de estatus - Formulario del affidavit of support, tambià ©n conocida como planilla de mantenimiento, I-864 - Prueba de cumplir con el  requisito de ingresos para patrocinar: W2 o 1099, copia de haber pagado impuestos (tax returns) en los à ºltimos aà ±os y una carta de la empresa o empleador para la que se trabaje en la que se especifique desde cundo se trabaja en dicha compaà ±Ãƒ ­a, quà © posicià ³n se ocupa y cul es el monto del salario anual. - Copia de las tres à ºltimas nà ³minas (pay stubs). - Formulario de informacià ³n biogrfica, que es el G-325A - Planilla de los resultados del examen mà ©dico, I-693 - Si se desea un permiso de trabajo antes de recibir la green card, llenar el formulario I-765 - Si se desea viajar fuera de Estados Unidos y regresar mientras se realiza la tramitacià ³n, puede que sea necesario llenar el formulario I-131 para el advance parole, o permiso para viajar. - El pago de la tarifa de todo el proceso. El Servicio de Inmigracià ³n y Ciudadanà ­a (USCIS, por sus siglas en inglà ©s) se pondr en contacto para la cita de datos biomà ©tricos.   El siguiente paso ser recibir el permiso de trabajo, tambià ©n conocido como EAD, si se ha solicitado uno. Despuà ©s, aproximadamente entre 2 y 4 meses de haber enviado la aplicacià ³n, se recibir una cita para la entrevista. En ella un empleado del USCIS intentar determinar si el matrimonio es de conveniencia, en cuyo caso se suspender la peticià ³n de la green card.   Es importante llevar a la entrevista documentacià ³n que sirva para acreditar que el matrimonio es de verdad, como por ejemplo: Cuentas bancarias a nombre de ambos asà ­ como la titularidad de propiedades que pertenezcan a los dos o hipotecas conjuntas.Pà ³lizas de seguros (incluidos mà ©dicos) a nombre de ambos o en los que uno de ellos sea beneficiario de la pà ³liza del otro, como por ejemplo en los casos de seguros de vida.Fotocopias a color y de calidad de fotografà ­as de la boda, de la fiesta de compromiso, si la hubiera habido, de la pareja sola y tambià ©n con miembros de la familia y amigos. Colocar 2 à ³ tres fotografà ­as en un folio en blanco y escribir en inglà ©s el nombre de las personas que aparecen, el lugar y la fecha en la que se tomaron. Repetir la operacià ³n cuantas veces sea necesario.Lease del alquiler de la vivienda, si lo hubiere o hipoteca.Copia de cualquier documento en el que figuren los nombres de ambos cà ³nyuges, como por ejemplo cualquier tipo de factura.Copia de la factura de telà ©fono que pueda probar la comunicacià ³n entre ambos cuando eran novios.Si lo hubi era, copia de los tiquetes de avià ³n para visitarse. Tambià ©n llevar identificacià ³n, incluido el pasaporte del cà ³nyuge extranjero. Si la entrevista es exitosa, se sellar el pasaporte del cà ³nyuge extranjero con una Tarjeta de Residencia temporal, que sirve para viajar y para trabajar. En el plazo de uno o dos meses se recibir la green card de plstico por correo.   Finalmente, si la green card se recibià ³ antes de cumplir dos aà ±os de casado, ser de carcter condicional. Dicha condicionalidad la hay que levantar a los dos aà ±os. Peticià ³n de ciudadano para cà ³nyuge extranjero que est fuera de Estados Unidos En este caso el proceso es un poco distinto. Se inicia con la peticià ³n con el formulario I-130 y envindose el pago por la tramitacià ³n y la documentacià ³n de apoyo que sirve para probar que existe un matrimonio, la ciudadanà ­a del solicitante y la identidad del solicitado (ver ms arriba en apartado anterior). Una vez que la peticià ³n es aprobada, el USCIS la envà ­a al Centro Nacional de Visas (NVC, por sus siglas en inglà ©s). Y sern ellos los que contacten y comiencen a pedir documentos y planillas, seguir las instrucciones al pie de la letra. Pedirn, entre otras cosas, el affidavit of support y todo lo relativo a probar que se tienen ingresos suficientes para patrocinar. Tambià ©n se darn instrucciones para el examen mà ©dico y, finalmente, para la entrevista en el consulado o embajada. Llevar toda la documentacià ³n que se indique. Si se pasa la entrevista, se recibe una visa de inmigrante que se estampa en el pasaporte. A partir de ese momento hay 6 meses para ingresar a los Estados Unidos. Y en ese momento, al llegar a un puerto de entrada terrestre, marà ­timo o de aeropuerto, se sella de nuevo el pasaporte con un sello de ingreso que junto a la visa de inmigrante equivale a una green card temporal, hasta que se recibe la de plstico. Al igual que sucede con el caso anterior, la green card de plstico es condicional si se recibe antes de llevar dos aà ±os de casado. En es caso hay que levantar dicha condicionalidad. Finalmente, destacar que si una persona est fuera de los Estados Unidos y piden a su nombre una green card, es muy difà ­cil que a partir de ese momento aprueben una peticià ³n de visa de turista. A tener en cuenta antes de iniciar los trmites para pedir a un cà ³nyuge De todas las cosas, dos destacan por su importancia y posibles consecuencias. En primer lugar hay que asegurarse de que se tienen ingresos suficientes o que se cuenta con un co-patrocinador. El USCIS no aprueba peticiones si no se cumple este requisito, no hay excepciones.   Y, en segundo lugar, informarse sobre las causas de denegacià ³n de la residencia. Y es que no es suficiente estar casado con un ciudadano. Hay que ser elegible para ingresar a los Estados Unidos y convertirse en residente. En algunos casos no es posible arreglar el problema. En otros es cuestià ³n de esperar a que pase el tiempo de castigo o, cuando se puede, pedir un perdà ³n, tambià ©n conocido como waiver o permiso. Esto à ºltimo hay que tenerlo especialmente en cuenta cuando el problema viene del hecho de haber estado ilegalmente en los Estados Unidos. Esto à ºltimo es un problema cuando se superan los 6 meses de ilegalidad  y se est fuera de Estados Unidos sin importar cà ³mo se habà ­a ingresado o cuando se est dentro y se ingresà ³ ilegalmente. Tambià ©n hay que tener en cuenta que en cosas del amor, las situaciones pueden cambiar. Si hay un cambio de opinià ³n por parte del ciudadano, podrà ­a poner fin a la peticià ³n.  Tambià ©n tener en cuenta que el divorcio, por parte de cualquiera de los cà ³nyuges, puede tener efectos migratorios importantes. Finalmente, para saber ms sobre la tarjeta de residencia se recomienda tomar este test de preguntas mà ºltiples, cuyas respuestas aclaran numerosas dudas. Este es un articulo informativo. No es asesorà ­a legal.

Unit 7 mini Coursework Example | Topics and Well Written Essays - 500 words

Unit 7 mini - Coursework Example It is important to note how long the carnival will last for a budget to be set. In this case it commences from the 11th to the 20th of September, 1998. A budget committee should be set for the selection process of any proposal. This helps in determining the amount of funds that will be allocated the carnival. Their work is to come up with a budget for every single detail that will be available. The budget proceedings also includes a charge incurred during the week of the carnival. In this case, the risk to be experienced will be overcharging the citizens since the people of Spokane County will take part in the selection of qualified firms for setting this event. The firm that submits an affordable and a well evaluated budget will stand a chance to secure the available carnival contract. Quality of products is a crucial aspect of getting into a contract with Spokane County. Nobody will want poor quality products of their carnival, it poses a risk not only to the firm but also to all the people attending the carnival. An opportunity in the contract exists where quality services are offered and well trained workers are employed based on the level knowledge and skills (Jaafari, 2001). Services offered have to meet the eye of the consumer. The major risks likely to be encountered with this field will be failure to satisfy consumers’ needs. This may lead to a termination of the contract mainly because it is a long term contract for up to 5years. The Spokane County Carnival is expected to have technical equipment such as carnival rides that are meant to satisfy the residents. The firm that provides these services and state of art equipment at reasonable fees lands the contract. According to Jaafari 2001, innovativeness is also crucial, people are accustomed to change, and hence the firm that comes up with new ideas, new carnival games, and shows have a

Gods and Humans Assignment Example | Topics and Well Written Essays - 750 words

Gods and Humans - Assignment Example Part of the reason both Oedipus and Antigone are considered to be classic works is that they feature characters who are larger than life and whose deeds are truly remarkable. Even centuries and millennium later the human and divine figures featured in these stories astonish us with their extreme and powerful qualities. We can marvel at these classical figures but we can also examine the different ways they interact with one another and the sorts of relationships they have with one another, plus the different ways Sophocles portrays them. Surely this interplay is one of the reasons these figures continue to resonate in our modern days and continue to excite us so much. The conflict between the world and laws of humans and those of gods is one that is truly timeless.In both quoted passages, the laws of the gods and the laws of human beings are examined and discussed. There are two clearly different principles at play. In both works the human heroes are at odds with the political system which is trying to subjugate them. In both cases, the heroes stand up for what they believe. They are willing to obey a higher law, a higher order which is in conflict with the human law before them. They do not recognize the arbitrarily exercised power of the regent. They operate under a different, more powerful law which they think is more objective, or more fair. Oedipus serves Apollo. Although he is blind he is capable of seeing that real life, full of human laws, is corrupt and false. The higher world of gods and forms is truer and more just. His blindness is perhaps something of an asset as it separates him somewhat from the human world and allows him to imagine or perceive of a more just world where the law of gods such as Apollo dominate. In Antigone much the same idea is presented. Antigone also must deal with Creon and the law of the human system. â€Å"[M]y reverence only brands me for irreverence!† she exclaims, weeping at the injustice of it. She has obeyed the religious ritual of burying her dead brother at the expense of the human law forbidding her to do so. That is why she is being punished. For her, obeying the gods is more important than obeying the king. And that is why she is willing to endure her punishment even if it is unjust in the human world.

Nordstrom Rewards Its Customers Essay Example for Free

Nordstrom Rewards Its Customers Essay Nordstrom is a great place to go shopping and receive rewards while spending money. Nordstrom shoppers automatically become members of Nordstrom’s Fashion Rewards program when they people sign up for the store’s credit. When each person accumulates 2,000 points, then they receive a $20 Nordstrom Note, a gift certificate redeemable for Nordstrom merchandise or services. In the book one of the questions is â€Å"what are the design characteristics of an effective loyalty program.† The structure of their loyalty program and how they use the data collected through the program to make informed product, marketing and customer experience decisions are key to its success. The store’s frequent customers will be able to get perks like custom shopping parties and tickets to in-store fashion shows after shelling out just half as much as they used to spend to qualify for rewards. Loyalty marketing is and should always be much bigger than points, thresholds or incentives. It is about changing and influencing behavior in a proactive manner that creates long-term brand advocates who, in turn, enter into a dialogue with the brand. Nordstrom’s program is effective for a number of key reasons. First, even the lower levels of Nordstrom’s loyalty program are engaging because they offer meaningful soft benefits and because it’s aspirational, members remain engaged; they aspire to be at the higher tiers in the program so they can get the bigger rewards. Another question asks is the Nordstrom program worth what it spends to reward customers. I think it does because when you reward your customers then they would want to come into the store and buy their supplies to build up their points. When they do that then they get awards. Example would be I have a credit card and I receive points, the more I spend then the more money I get off from that store. I use my card all the time and I go and pay it off. I would get a credit card from any store I shop at if they reward me to use it.

Non-steroidal Anti-inflammatory Drugs: Mechanisms of Action

Non-steroidal Anti-inflammatory Drugs: Mechanisms of Action Non-steroidal anti-inflammatory drugs are a type of drugs that can be used as pain killers. Nowadays, other pain killers such as paracetamol are more widely used, as they have fewer side effects, and cost less. However, NSAIDs are mostly used in conditions which cause inflammation. It may take from a few days to more than three weeks to show their anti-inflammatory effects. They are specifically used to treat arthritis, menstrual cramps, sports injuries, and headaches. There are different types of NSAIDs that are used in different situations. For example, Ketorolac (Toradol) is only used for short-term treatment of moderately severe acute pain that otherwise would be treated with opioids. (Ogbru, 1997). Aspirin is also a NSAID that is used long-term, at low doses, specifically to inhibit blood clot formation and prevent heart attacks and strokes in individuals at high risk for developing blood clots. The most common and undesirable side effects of NSAIDs are nausea, vomiting, diarrhoea, decreased appetite, constipation, rash, dizziness and headache. The most severe side effects are kidney failure, liver failure, ulcers and prolonged bleeding after an injury or surgery (Ogbru, 1997). Mechanisms of Action Prostaglandins are a group of lipid compounds that are produced by specific group of enzymes called cyclooxygenases from arachidonic acid (Zeilhofer, 2007), which promote vital functions in inflammation, pain, fever; support the blood clotting function of platelets; and protect the lining of the stomach from the damaging effects of acid (Ogbru, 1997) (Figure 1). Mode of action of NSAIDs is to exert anti-inflammatory, analgesic (pain relieving), and antipyretic (fever-reducing) effects through the blockade of prostaglandin synthesis via non-selective inhibition of cyclooxygenases (COX-1 and COX-2) isozymes (Chakraborti et al., 2010). Both COX-1 and COX-2 enzymes produce prostaglandins that serve inflammation, pain and fever. However, only COX-1 produces and regulates prostaglandins that protect the stomach (gastrointestinal) and support platelets (Ogbru, 1997) (Figure 2). NSAIDs reduce the concentration of prostaglandins throughout the body by blocking the COX enzymes. As a result of this, ongoing inflammation, pain and fever are decreased. For example, when concentration of prostaglandin E2 (PGE2) elevates in certain parts of the brain, body temperature increases. This increase in body temperature changes the firing rate of neurons that control thermoregulation in the hypothalamus. Aspirin which can act as an antipyretic, work by inhibiting the enzyme cyclooxygenase and reducing the levels of PGE2 within the hypothalamus of the brain. As a consequence, body temperature falls, and fever is relieved (Aronoff Neilson, 2001). It is important to understand that the pain pathway is not the same for fever and other cases like tissue injuries. In tissue injury, prostaglandins together with other agents like histamine, act on the sensory neurons present in the injured or stimulated tissue which in turn conduct the generated signal to the spinal cord. The afferent fibres (neurons) transmit the pain signal to the spinal cord. The signal is then propagated from the spinal cord to the pain centres in brain. This is carried out by synapse formation between afferent sensory neuron in the dorsal root ganglion of the spinal cord, transferring the signal up the spinothalamic tract to synapse in the thalamus. Therefore the final synapse with the primary sensory cortex fibres occurs in the thalamus (Lorne, 2010) (Figure 3 4). As a result of this, pain centres in brain will become alerted and body will feel the pain. Therefore, prostaglandin synthesis inhibition by NSAIDs will result in pain pathway blockage, hence reduc ing or killing the pain. Irrespective of the type of injured tissue (ligament, tendon or muscle), the body reacts to injury with a sequence of events that initiates with an influx of inflammatory cells and blood. Removal of debris and recruiting growth factors e.g. cytokines toward the injury site are the subsequent events that are carried out by the inflammatory cells. The same Prostaglandins that are blocked by NSAIDs are partly involved in this inflammatory stage. In a normal healing process (without application of NSAIDs), a proliferative stage consisting of a mixture of fibroblasts and inflammatory cells naturally follows the inflammatory stage. At this stage, the fibroblasts construct a new extracellular matrix and continue into the maturation stage (final stage) where functional tissue is laid down. The crucial point is that each stage of repair is a prerequisite for the subsequent stage. Hence, although blocking the inflammatory stage by NSAIDs relieves the pain, it may delay the healing of musculosk eletal injuries (Stovitz Johnsons, 2003). Side effects of NSAIDs such as ulcers and bleeding promotion are due to reduction in bodys prostaglandin level which protects the stomach and supports platelets and blood clotting. In other words, NSAIDs like aspirin, especially in high doses, act as pain killers by reducing prostaglandin concentration; however, this reduction can also raise severe unwanted effects like ulcers (Ogbru, 1997). There are various NSAIDs in terms of potency, duration of action, body elimination manner, how strongly they inhibit COX-1 and their tendency to cause ulcers or promote bleeding. The more an NSAID blocks COX-1, the greater is its tendency to cause ulcers and promote bleeding. One NSAID,  celecoxib  (Celebrex), blocks COX-2 but has little effect on COX-1, and is therefore further classified as a selective COX-2 inhibitor. Selective  COX-2 inhibitors  cause less bleeding and fewer ulcers than other NSAIDs. (Ogbru, 1997). Rofecoxib (tradename = Vioxx) In 1999, two new highly selective COX-2 inhibitors, known as coxibs (celecoxib and rofecoxib) which were claimed to have low gastrointestinal (GI) side effects were introduced which resulted in high commercial development. Rofecoxib (Vioxx) was introduced by Merck (one of the largest pharmaceutical companies) as a more effective and a safer alternative to NSAIDs for the treatment of pain associated with osteoarthritis (Krumholz et al., 2007). While found to have fulfilled these goals in part, a worrying series of events took place in the late 2004 period when rofecoxib was withdrawn worldwide from the market because of alarming cardiovascular incidents and concerns about increased risk of heart attack and stroke due to long-term, high-dosage use. Other coxibs were subsequently withdrawn on suspicion of having the same adverse effects, although to a varying degree (Rainsford, 2007). Previous to introducing the drug to the market, it were concerned that the drug might have adverse effects on the cardiovascular system by changing prostacyclin to thromboxane ratio, which have opposite effects on regulating blood flow and clotting. (Prostacyclin and thromboxane are members of the family of lipids known as eicosanoids.) (Krumholz et al., 2007) A study sponsored by Merck during 1996-1997 reported that rofecoxib decreased the concentration of prostacyclin metabolites in urine in healthy volunteers by about half. Merck officials sought to soften  the academic authors interpretation that COX-2 inhibition within the vascular endothelium may increase the propensity for thrombus formation, the basis of what became  known as the FitzGerald hypothesis. The academic authors changed  the manuscript at Mercks request-for example, they changed  systemic biosynthesis of prostacyclin was decreased by  [rofecoxib] to Cox-2 may play a role in the systematic biosynthesis  of prostacyclin. (Krumholz et al., 2007). However, despite knowing that rofecoxib may elevate thrombus formation, none of the studies that constituted Mercks new drug application to the Food and Drug Administration (FDA) in 1998 were designed to examine cardiovascular risk. The studies were all generally small, had short treatment periods, enrolled patients at low risk of cardiovascular disease, and did not have a standardised procedure to collect cardiovascular results (Krumholz et al., 2007). In 1999, the largest study on rofecoxib, the vioxx gastrointestinal outcomes research (VIGOR), took place by Merck. The purpose of the study was to show that the drug would have fewer GI side effects than naproxen (NSAID) for the treatment of rheumatoid arthritis. The study took place without a standard procedure for collecting information on cardiovascular events. Finally, the study showed that rofecoxib was not more effective in terms of mitigating symptoms of arthritis but halved the risk of GI events. However, the study showed that there was also evidence of an increased risk of myocardial infarction. Therefore, the first suspicion about the metabolite meanings i.e. urine prostacyclin data was right. Nevertheless, Merck decided to propose a naproxen assumption, implying that rofecoxib had not been harmful but that naproxen had been protective, despite having no evidence that naproxen had a protective effect on cardiovascular system (Krumholz et al., 2007). Finally, after wide usage of Vioxx in clinical centres around the world for around 5 years, due to an increase in serious cardiovascular events, the company voluntarily withdrew Vioxx from the market, in 2004. Currently, a lot of studies are taking place to discover why cardiovascular failures took place with coxibs, to identify safer coxibs, and to clarify the roles of COX-2 and COX-1 in cardiovascular diseases and stroke in order to develop newer agents to control these conditions (Rainsford, 2007). Overall, in order to improve the care of patients and gain their trust back, putting patients interests first is necessary. A renewed commitment and re-establishing collaborations between industry, academics, journals and practising doctors are the only way to extract something positive from this unfortunate event.

Tourism and it’s negative Effects

While tourism can be a powerful positive force for change in poor countries, it can also be seriously damaging for the local environment and culture. An increase in mass tourism that is not controlled responsibly can ruin areas of natural beauty. com/the-economic-impact-of-tourism/">Tourism can damage coral reefs, pollute beaches and destroy the habitats of wildlife as roads and hotels are built. Ironically, damage to these natural resources is likely to reduce future numbers of visitors. Another negative effect is that the increasing numbers of aeroplane ?ights are a major cause of global warming.A second problem is that the tourist resorts are frequently owned by large Western companies and all too often the pro?ts earned from tourism go straight into the bank accounts of these companies. Moreover, the well-paid managerial positions are often held by foreigners, and the wages given to local hotel employees are usually very low. Where this is the case, very little money enters the l ocal economy at all. By purchasing souvenirs, food and other goods from local people you can help to spread the bene?ts of tourism.Finally, tourism can have an adverse effect on local culture, traditions and the way of life. Large numbers of tourists can undermine traditional beliefs, values and customs and in particular risk commercialising the culture that they ?nd so interesting. And where these tourists are insensitive to local traditions their behaviour can cause great offence. Tourism Fact File  · Tourism employs 250 million people, roughly one in ten of the world's workforce.  · 80% of the people that travel internationally come from the USA, Canada, Japan and 17 European countries, including the UK. · 15 million Britons take package holidays abroad each year.  · The developing world's share of the tourist trade has increased by an average of 9. 5% a year since 1990.  · The amount of money that leaves a destination country (the country where people spend their holid ay) varies from 40% out of India, and 80% out of the Caribbean islands.  · The UN calculates that the amount of water used by an average tourist in 24 hours would be enough to grow rice for an individual for 100 days.  · An 18-hole golf course in a dry country can use as much water as a town of 10,000 people.